Lyra Therapeutics Inc (LYRA) Ownership

0.11 ↑0.01 (5.95%)

As of December 31, 1969, 7:00pm EST.

Institutions
Mutual Funds

Institutional Ownership

Perceptive Advisors LLC is the biggest individual institutional holder of Lyra Therapeutics Inc (LYRA), owning a total of 12.8 million shares. Combined, the top 62 institutional holders of LYRA own 85.62% of the company with a total of 55 million shares.

In the latest ownership report on December 31st 2024, the top 62 institutional holders increased their combined ownership of LYRA by 515 thousand shares. 12 institutions bought 1,912,991 total additional shares and increased their ownership by an average of 142.88%. However 4 institutions sold 1,397,818 total shares and decreased their ownership by an average of 34.51%.

Overall this is a positive sign as the number of shares owned by the top 20 institutional holders of Lyra Therapeutics Inc increased by a net total of 515,173 in the latest quarter.

Institution Ownership Chart

Latest Institutional Ownership Changes

Owner	Percent Owned	Percent Change	Shares Owned	Share Change	Date Reported
Perceptive Advisors LLC	19.365%	0.000%	12,757,562	0	2024-12-31
BlackRock Inc	4.720%	3.881%	3,109,798	116,172	2024-12-31
Samsara BioCapital, LLC	2.984%	-29.298%	1,965,689	-814,572	2024-12-31
Vanguard Group Inc	2.713%	0.459%	1,787,422	8,159	2024-12-31
Ikarian Capital, LLC	1.606%	0.125%	1,058,148	1,319	2024-12-31
Geode Capital Management, LLC	1.345%	15.302%	885,966	117,578	2024-12-31
Goldman Sachs Group Inc	0.843%	1.493%	555,508	8,169	2024-12-31
ADAR1 Capital Management LLC	0.809%	0.000%	533,200	533,200	2024-12-31
State Street Corp	0.742%	0.000%	488,720	0	2024-12-31
UBS Group AG	0.645%	1,605.660%	424,965	400,050	2024-12-31
Two Sigma Advisers, LLC	0.585%	-16.250%	385,500	-74,800	2024-12-31
Qube Research & Technologies	0.519%	0.000%	342,159	342,159	2024-12-31
Northern Trust Corp	0.435%	56.211%	286,310	103,026	2024-12-31
BNP Paribas Arbitrage, SA	0.372%	0.000%	244,920	244,920	2024-12-31
BOOTHBAY FUND MANAGEMENT, LLC	0.355%	0.567%	233,989	1,319	2024-12-31
Morgan Stanley - Brokerage Accounts	0.329%	-66.816%	216,485	-435,896	2024-12-31
Two Sigma Investments LLC	0.319%	-25.677%	209,997	-72,550	2024-12-31
JPMorgan Chase & Co	0.238%	30.890%	156,442	36,920	2024-12-31
New York State Common Retirement Fund	0.235%	0.000%	154,800	0	2024-12-31
Charles Schwab Investment Management Inc	0.169%	0.000%	111,609	0	2024-12-31

Top Institutions

Owner	Percent Owned	Percent Change	Shares Owned	Share Change	Date Reported
Perceptive Advisors LLC	19.365%	0.000%	12,757,562	0	2024-12-31
Citadel Advisors Llc	7.292%	0.000%	4,772,816	0	2024-09-30
BlackRock Inc	4.720%	3.881%	3,109,798	116,172	2024-12-31
Nantahala Capital Management, LLC	4.627%	-65.175%	2,820,982	-5,279,454	2024-03-31
Point72 Asset Management, L.P.	4.498%	0.000%	2,742,460	2,742,460	2024-03-31
VR Adviser, LLC	3.936%	178.747%	2,576,093	1,651,923	2024-03-31
Samsara BioCapital, LLC	2.984%	-29.298%	1,965,689	-814,572	2024-12-31
Vanguard Group Inc	2.713%	0.459%	1,787,422	8,159	2024-12-31
PURA VIDA INVESTMENTS, LLC	2.159%	0.000%	1,413,242	0	2024-03-31
Armistice Capital, LLC	1.785%	-29.807%	1,088,000	-462,000	2023-12-31
Ikarian Capital, LLC	1.606%	0.125%	1,058,148	1,319	2024-12-31
Rosalind Advisors, Inc.	1.581%	-9.589%	1,034,773	-109,751	2024-06-30
Ally Bridge Group (NY) LLC	1.533%	0.000%	1,003,741	1,003,741	2024-03-31
SEI Investments Co	1.524%	0.000%	997,782	997,782	2024-09-30
Tri Locum Partners LP	1.495%	0.000%	978,793	978,793	2024-03-31
Geode Capital Management, LLC	1.345%	15.302%	885,966	117,578	2024-12-31
Vestal Point Capital LP	1.312%	-73.333%	800,000	-2,200,000	2024-03-31
Verition Fund Managegment, LLC	1.174%	0.000%	768,214	768,214	2024-03-31
LAURION CAPITAL MANAGEMENT LP	1.143%	0.000%	747,827	747,827	2024-03-31
Woodline Partners LP	1.110%	12.764%	676,554	76,579	2024-03-31
Parkman Healthcare Partners LLC	1.054%	-14.922%	642,245	-112,640	2024-03-31
Soleus Capital Management, L.P.	1.127%	0.000%	592,417	0	2023-09-30
Ensign Peak Advisors Inc	0.970%	96.102%	591,311	289,778	2024-03-31
Goldman Sachs Group Inc	0.843%	1.493%	555,508	8,169	2024-12-31
Amvescap Plc.	0.848%	0.000%	555,233	555,233	2024-03-31
ADAR1 Capital Management LLC	0.809%	0.000%	533,200	533,200	2024-12-31
Walleye Trading Advisors, LLC	0.807%	3,419.380%	528,118	513,112	2024-03-31
State Street Corp	0.742%	0.000%	488,720	0	2024-12-31
UBS Group AG	0.645%	1,605.660%	424,965	400,050	2024-12-31
Millennium Management LLC	0.621%	24.579%	406,121	80,126	2024-03-31
Two Sigma Advisers, LLC	0.585%	-16.250%	385,500	-74,800	2024-12-31
Dafna Capital Management LLC	0.729%	0.000%	361,084	361,084	2023-06-30
Schonfeld Strategic Advisors LLC	0.546%	0.000%	357,319	357,319	2024-03-31
Susquehanna International Group, LLP	0.525%	32.344%	343,322	83,906	2024-03-31
Qube Research & Technologies	0.519%	0.000%	342,159	342,159	2024-12-31
Northern Trust Corp	0.435%	56.211%	286,310	103,026	2024-12-31
Everhart Financial Group, Inc.	0.386%	0.000%	252,708	252,708	2024-09-30
Hudson Bay Capital Management LP	0.410%	0.000%	250,000	250,000	2024-03-31
BNP Paribas Arbitrage, SA	0.372%	0.000%	244,920	244,920	2024-12-31
BOOTHBAY FUND MANAGEMENT, LLC	0.355%	0.567%	233,989	1,319	2024-12-31
Morgan Stanley - Brokerage Accounts	0.329%	-66.816%	216,485	-435,896	2024-12-31
Two Sigma Investments LLC	0.319%	-25.677%	209,997	-72,550	2024-12-31
Dimensional Fund Advisors, Inc.	0.313%	69.563%	190,986	78,352	2024-03-31
Longwood Capital Partners LLC	0.284%	0.000%	173,320	173,320	2024-03-31
ExodusPoint Capital Management, LP	0.243%	0.000%	159,238	159,238	2024-09-30
JPMorgan Chase & Co	0.238%	30.890%	156,442	36,920	2024-12-31
New York State Common Retirement Fund	0.235%	0.000%	154,800	0	2024-12-31
Bridgeway Capital Management, LLC	0.233%	0.000%	141,800	0	2023-12-31
Alyeska Investment Group, L.P.	0.249%	-72.824%	130,839	-350,607	2023-09-30
SIMPLEX TRADING, LLC	0.197%	0.000%	129,141	129,141	2024-06-30
Bank of Montreal	0.182%	0.000%	119,379	119,379	2024-09-30
BMO Capital Markets Corp.	0.182%	0.000%	119,379	119,379	2024-09-30
Clearline Capital LP	0.182%	0.000%	119,128	0	2024-06-30
Charles Schwab Investment Management Inc	0.169%	0.000%	111,609	0	2024-12-31
State Street Corporation	0.192%	70.455%	95,080	39,300	2023-09-30
Bank of America Corp	0.132%	-45.827%	86,459	-73,138	2024-06-30
Bank of New York Mellon Corp	0.118%	0.000%	77,423	77,423	2024-06-30
Renaissance Technologies Corp	0.143%	48.377%	71,000	23,149	2023-06-30
CVI Holdings LLC	0.191%	0.000%	60,822	60,822	2022-06-30
Alpine Partners VI, LLC	0.071%	0.000%	46,439	46,439	2024-06-30
Anson Funds Management LP	0.123%	0.000%	39,127	39,127	2022-12-31
Letko, Brosseau & Associates Inc	0.064%	0.000%	31,900	31,900	2023-06-30

Mutual Fund Ownership

iShares Russell 2000 ETF is the biggest individual fund holder of Lyra Therapeutics Inc (LYRA), owning a total of 2.4 million shares. Combined, the top 65 mutual fund holders of LYRA own 15.42% of the company with a total of 9.9 million shares.

In the latest ownership report on March 31st 2025, the top 65 fund holders increased their combined ownership of LYRA by 315 thousand shares. 7 funds bought 337,527 total additional shares and increased their ownership by an average of 230.89%. However 2 funds sold 22,451 total shares and decreased their ownership by an average of 0.67%.

Overall this is a positive sign as the number of shares owned by the top 20 mutual funds holding Lyra Therapeutics Inc increased by a net total of 315,076 in the latest report.

Mutual Funds Chart

Latest Mutual Fund Ownership Changes

Owner	Percent Owned	Percent Change	Shares Owned	Share Change	Date Reported
iShares Russell 2000 ETF	3.595%	-0.859%	2,368,365	-20,515	2025-03-31
Vanguard Total Stock Mkt Idx Inv	1.507%	0.000%	992,543	0	2025-03-31
Vanguard Institutional Extnd Mkt Idx Tr	0.692%	0.000%	455,832	0	2025-03-31
iShares Russell 2000 Growth ETF	0.618%	-0.474%	406,931	-1,936	2025-03-31
Vanguard Russell 2000 ETF	0.344%	2.291%	226,628	5,076	2025-03-31
Schwab Small Cap Index	0.169%	0.000%	111,609	0	2025-03-31
iShares Micro-Cap ETF	0.168%	0.000%	110,386	0	2025-03-31
NT R2000 Index Fund - NL	0.143%	546.845%	94,297	79,719	2025-03-31
NT R2000 Index Fund - DC - NL - 2	0.114%	533.406%	75,331	63,438	2025-03-31
NT R2000 Index Fund - DC - NL - 3	0.114%	533.406%	75,331	63,438	2025-03-31
Extended Equity Market Fund K	0.107%	0.307%	70,478	216	2025-03-31
Northern Small Cap Index	0.099%	0.000%	65,440	65,440	2025-03-31
State Street Russell 2000 Value CIT	0.091%	0.000%	60,200	60,200	2025-03-31

Top Mutual Funds

Owner	Percent Owned	Percent Change	Shares Owned	Share Change	Date Reported
iShares Russell 2000 ETF	3.595%	-0.859%	2,368,365	-20,515	2025-03-31
Vanguard US Total Market Shares ETF	1.507%	0.000%	992,545	2	2024-09-30
Vanguard Total Stock Mkt Idx Inv	1.507%	0.000%	992,543	0	2025-03-31
Invesco Dorsey Wright SmallCap Momt ETF	0.972%	0.000%	592,700	0	2024-06-30
Vanguard Institutional Extnd Mkt Idx Tr	0.692%	0.000%	455,832	0	2025-03-31
iShares Russell 2000 Growth ETF	0.618%	-0.474%	406,931	-1,936	2025-03-31
Fidelity Small Cap Index	0.481%	-1.838%	317,100	-5,938	2025-01-31
Vanguard Extended Market Index Investor	0.609%	0.000%	301,686	0	2023-08-31
Vanguard Russell 2000 ETF	0.344%	2.291%	226,628	5,076	2025-03-31
Fidelity Extended Market Index	0.341%	-0.633%	224,532	-1,430	2025-02-28
Russell 3000 Screened Index Composite	0.283%	0.000%	186,700	186,700	2024-09-30
Fidelity® Extended Market Index	0.300%	0.000%	157,903	0	2023-11-30
Spartan Total Market Index Pool E	0.213%	0.000%	140,133	0	2025-02-28
Spartan Total Market Index Pool G	0.213%	0.000%	140,133	0	2025-02-28
Northern Trust Russell 2000 Growth Index	0.206%	638.040%	136,006	117,578	2024-12-31
NT R2000 Growth Index Fund - L	0.206%	638.040%	136,006	117,578	2024-12-31
Schwab Small Cap Index	0.169%	0.000%	111,609	0	2025-03-31
iShares Micro-Cap ETF	0.168%	0.000%	110,386	0	2025-03-31
NT R2000 Index Fund - NL	0.143%	546.845%	94,297	79,719	2025-03-31
RIM Global Bioscience EUR	0.139%	0.000%	91,272	91,272	2024-04-30
Bridgeway Ultra-Small Company Market	0.130%	-39.314%	84,900	-55,000	2024-03-31
APO Medical Opportunities R	0.154%	-21.651%	75,992	-21,000	2023-05-31
NT R2000 Index Fund - DC - NL - 2	0.114%	533.406%	75,331	63,438	2025-03-31
NT R2000 Index Fund - DC - NL - 3	0.114%	533.406%	75,331	63,438	2025-03-31
Northern Trust Russell 2000 Index	0.109%	934.544%	72,087	65,119	2024-12-31
BlackRock Extended Equity Market K	0.109%	-0.042%	71,229	-30	2024-09-30
NT R2000 Index Fund - L	0.107%	933.021%	70,607	63,772	2024-12-31
Extended Equity Market Fund K	0.107%	0.307%	70,478	216	2025-03-31
Northern Small Cap Index	0.099%	0.000%	65,440	65,440	2025-03-31
State Street Russell 2000 Value CIT	0.091%	0.000%	60,200	60,200	2025-03-31
Fidelity Total Market Index	0.090%	0.000%	59,560	0	2025-02-28
DFA US Micro Cap I	0.087%	0.000%	53,050	0	2024-04-30
Fidelity® Total Market Index	0.095%	0.000%	49,733	0	2023-11-30
The Vanguard Russell 2000 Growth Index	0.075%	0.000%	49,432	0	2025-02-28
Russell Personalized DI All Cap SMA	0.073%	0.000%	47,932	0	2024-12-31
Spartan Small Cap Index Pool	0.068%	15.405%	44,484	5,938	2025-01-31
Fidelity Series Total Market Index	0.066%	0.000%	43,122	0	2025-01-31
Fidelity® Series Total Market Index	0.073%	0.000%	38,152	0	2023-11-30
LVIP SSgA Small Cap Index Std	0.058%	0.000%	37,900	37,900	2024-09-30
Fidelity Nasdaq Composite Index	0.056%	0.000%	36,348	0	2024-07-31
NT R2000 Value Index Fund - L	0.055%	0.000%	36,041	36,041	2024-12-31
Fidelity® NASDAQ Composite Index®	0.059%	0.000%	30,754	0	2023-10-31
NT Ext Equity Mkt Idx Fd - NL	0.045%	0.000%	29,304	0	2024-09-30
Northern Trust Extended Eq Market Idx	0.045%	0.000%	29,226	0	2024-09-30
NT Ext Equity Mkt Idx Fd - L	0.045%	0.000%	29,226	0	2024-09-30
Vanguard Balanced Index Inv	0.046%	0.000%	28,249	0	2024-04-30
DFA US Small Cap I	0.044%	70.812%	26,563	11,012	2024-04-30
Global X Russell 2000 ETF	0.040%	0.000%	26,426	0	2024-10-31
Avantis US Small Cap Equity ETF	0.042%	0.000%	25,100	0	2024-03-29
NT Ext Equity Mkt Idx Fd - DC - NL - T2	0.036%	0.306%	23,610	72	2024-09-30
Vanguard Russell 2000 Growth ETF	0.034%	-2.170%	22,412	-497	2024-08-31
Vanguard Instl Ttl Stck Mkt Idx Tr	0.036%	-6.531%	21,838	-1,526	2024-03-31
Vanguard Instl Ttl Stk Mkt Idx InstlPls	0.036%	0.000%	21,838	0	2024-04-30
Dimensional US Core Equity 2 ETF	0.035%	0.000%	21,455	0	2024-06-28
MEDICAL BioHealth EUR Acc	0.035%	-87.452%	17,186	-119,777	2023-05-31
Mandarine Global Microcap G EUR	0.025%	-14.261%	15,006	-2,496	2024-03-31
Mandarine Global Microcap M EUR	0.025%	0.000%	13,990	13,990	2023-12-31
Dimensional US Small Cap ETF	0.022%	0.000%	12,752	0	2024-02-29
SSgA U.S. Extended Market Index Class I	0.021%	148.980%	12,200	7,300	2023-12-31
State St US Extended Mkt Indx NL Cl C	0.023%	0.000%	12,200	0	2024-01-31
Vanguard U.S. Eq Idx £ Acc	0.019%	0.000%	10,618	0	2024-02-29
Spartan Extended Market Index Pool E	0.018%	0.000%	9,609	0	2023-11-30
Schwab Total Stock Market Index	0.017%	0.000%	9,060	0	2023-11-30
apo Medical Opportunities Institutionell	0.022%	-58.682%	7,041	-10,000	2023-03-31
Dimensional Global Small Coms USD Acc	0.011%	0.000%	5,614	5,614	2023-09-30