Biotechnology

Biotechnology stocks and their performance, sorted by market cap.

Home » Stock Market Industries » Biotechnology

Performance
(Last 24 Hours)

N/A

Performance
(Last 14 Days)

N/A

Number Of Biotechnology Stocks

739

Market Capitalization
(Average)

2.1B

List Of Biotechnology Stocks

NameTickerMarket CapLast Closing Price52-Week High52-Week Low
Novo Nordisk A/SNVO482.1B103.44146.3685.00
Vertex Pharmaceuticals IncVRTX102.1B396.64516.74392.81
Regeneron Pharmaceuticals IncREGN77.8B708.251201.76701.85
Seagen IncSGEN43.2B228.88228.90125.01
Alexion Pharmaceuticals IncALXN40.3B182.50186.61100.51
argenx NV ADRARGX38.3B626.03638.33356.01
Alnylam Pharmaceuticals IncALNY30.8B238.87300.55143.31
BioNTech SEBNTX26.7B111.34124.7178.36
BeiGene LtdBGNE19.8B174.72246.04129.52
United Therapeutics CorporationUTHR16.1B360.16410.00210.76
Moderna IncMRNA15.2B39.56166.6136.85
Royalty Pharma PlcRPRX14.3B24.2830.6124.28
Neurocrine Biosciences IncNBIX13.7B134.96153.15111.62
Summit Therapeutics PLCSMMT13.6B18.4031.932.39
Genmab ASGMAB13.3B20.0932.7720.02
Incyte CorporationINCY12.9B67.0683.3851.18
Karuna Therapeutics IncKRTX12.6B329.83329.83161.01
Insmed IncINSM12.4B69.4179.0122.00
Biomarin Pharmaceutical IncBMRN12.4B65.0099.0061.93
Sarepta Therapeutics IncSRPT11.4B119.47163.8593.70
Bio-Techne CorpTECH11.3B71.3983.9761.93
Acceleron Pharma IncXLRN11B178.75182.78113.75
Vaxcyte IncPCVX10.7B86.21117.9359.79
Exelixis IncEXEL9.6B33.6836.4620.17
Prometheus Biosciences IncRXDX9.5B199.92199.9225.49
Intracellular ThITCI8.9B84.1491.5764.37
ImmunoGen IncIMGN8.7B31.2331.233.67
Ascendis Pharma ASASND8.2B137.74159.40112.93
Cerevel Therapeutics Holdings IncCERE8.2B44.9644.9620.26
Revolution Medicines IncRVMD8B43.2960.6026.56
Immunomedics IncIMMU7.8B0.0033.438.80
Jazz Pharmaceuticals PLCJAZZ7.4B122.85132.77100.57
Reata Pharmaceuticals IncRETA6.6B172.36172.3622.15
Madrigal Pharmaceuticals IncMDGL6.4B293.41354.85171.37
Legend Biotech CorpLEGN6.2B34.0269.9933.01
Arena Pharmaceuticals IncARNA6.2B99.9999.9945.80
Halozyme Therapeutics IncHALO6B47.3264.4233.68
MyoKardia IncMYOK5.7B0.00122.4942.65
Blueprint Medicines CorpBPMC5.6B88.93120.5073.17
Ionis Pharmaceuticals IncIONS5.6B35.5953.5533.73
Abcam PLCABCM5.5B23.9924.4712.62
Cytokinetics IncCYTK5.5B46.74108.0645.71
IVERIC bio IncISEE5.5B39.9539.959.44
Corcept Therapeutics IncorporatedCORT5.4B51.1560.8521.10
BridgeBio Pharma IncBBIO5B26.2143.8922.35
Crinetics Pharmaceuticals IncCRNX4.9B52.7460.6934.76
Alkermes PlcALKS4.8B29.9732.5623.01
TG Therapeutics IncTGTX4.8B30.9535.0913.02
Krystal Biotech IncKRYS4.6B160.83213.66108.01
Viking Therapeutics IncVKTX4.6B41.4994.5017.40
Global Blood Therapeutics IncGBT4.6B68.4968.4922.30
Forty Seven IncFTSV4.6B0.0095.515.53
China Biologic Products Holdings IncCBPO4.6B0.00119.99101.98
Alpine Immune Sciences IncALPN4.5B7.8064.970.00
Axsome Therapeutics IncAXSM4.3B89.74100.4965.72
ADMA Biologics IncADMA4.2B17.9022.624.36
Mirati TherMRTX4.1B58.7062.3827.80
Apellis Pharmaceuticals IncAPLS4.1B33.1472.4726.18
Arcellx IncACLX4.1B75.21106.5349.74
UltragenyxRARE4B43.4759.3637.42
Scholar Rock Holding CorpSRRK3.9B42.0945.487.07
Turning Point Therapeutics IncTPTX3.8B76.0181.9924.32
Immunovant IncIMVT3.8B25.6644.1925.10
ChemoCentryx IncCCXI3.7B51.9951.9915.36
Cymabay TherapeuCBAY3.7B32.4832.487.47
Avidity Biosciences IncRNA3.7B31.0552.509.05
Biohaven Pharmaceutical Holding Co LtdBHVN3.6B35.3459.7532.77
NantKwest IncNK3.6B33.9046.1412.83
PTC Therapeutics IncPTCT3.5B45.2552.0724.15
Crispr Therapeutics AGCRSP3.4B40.3989.1240.39
Rhythm Pharmaceuticals IncRYTM3.4B55.4867.3335.41
Verona Pharma PLC ADRVRNA3.4B41.2242.6811.48
Denali Therapeutics IncDNLI3.1B21.4931.5814.96
Veracyte IncVCYT3B39.0744.4018.86
Zai Lab LtdZLAB3B26.2233.1813.72
Xenon Pharmaceuticals IncXENE3B38.9050.0436.12
Dicerna Pharmaceuticals IncDRNA3B38.2239.9919.26
Viela Bio IncVIE2.9B0.0060.2121.50
Amicus Therapeutics IncFOLD2.9B9.7314.529.04
Merus BVMRUS2.9B42.0960.2027.50
Morphic Holding IncMORF2.9B56.9956.9919.95
MorphoSys AG ADRMOR2.9B18.9619.344.55
ACADIA Pharmaceuticals IncACAD2.8B16.7331.7714.29
Vericel Corp OrdVCEL2.7B54.9559.1132.52
Chinook Therapeutics IncKDNY2.7B40.3940.3918.46
Myovant Sciences LtdMYOV2.6B26.9827.027.78
SpringWorks Therapeutics IncSWTX2.6B34.7852.5028.61
HUTCHMED DRCHCM2.6B14.6121.7812.08
Catalyst Pharmaceuticals IncCPRX2.6B21.4623.9313.18
Kymera Therapeutics IncKYMR2.5B39.1452.4022.90
Arrowhead Pharmaceuticals IncARWR2.4B19.5039.4817.70
Protagonist Therapeutics IncPTGX2.4B39.5448.4321.79
Longboard Pharmaceuticals IncLBPH2.3B59.9859.983.96
Centessa Pharmaceuticals PLC ADRCNTA2.3B17.5518.676.73
Provention Bio IncPRVB2.3B24.9824.983.43
Ra Pharmaceuticals IncRARX2.3B0.0048.0219.64
Dice Molecules Holdings LLCDICE2.3B47.5547.5515.44
Beam Therapeutics IncBEAM2.2B26.8545.0721.22
Geron CorporationGERN2.2B3.665.091.75
Deciphera Pharmaceuticals LLCDCPH2.2B25.5925.5910.11
Iovance Biotherapeutics IncIOVA2.2B7.2217.477.22
Ligand Pharmaceuticals IncorporatedLGND2.2B113.95129.9068.53
Ideaya Biosciences IncIDYA2.1B24.7947.1324.79
Principia Biopharma IncPRNB2.1B0.0075.6525.35
Agios PharmAGIO2B35.8161.6421.32
Wave Life Sciences LtdWVE2B13.1916.443.54
Tarsus Pharmaceuticals IncTARS2B52.0053.2619.61
Akero Therapeutics IncAKRO2B28.4035.2817.76
Mirum Pharmaceuticals IncMIRM2B41.1346.6523.57
Immunitybio IncIBRX1.9B2.679.152.62
Harmony Biosciences HoldingsHRMY1.9B33.8941.4928.81
Trillium Therapeutics IncTRIL1.9B18.4420.135.86
BELLUS Health Inc.BLU1.9B14.7414.756.46
Fusion Pharmaceuticals IncFUSN1.8B21.5521.552.37
Galapagos NV ADRGLPG1.8B26.3742.4424.20
Ambrx Biopharma Inc. American Depositary SharesAMAM1.8B28.000.000.00
Five Prime Therapeutics IncFPRX1.8B0.0038.002.79
MannKind CorpMNKD1.7B6.307.443.25
Certara IncCERT1.7B10.5519.459.55
Celldex Therapeutics IncCLDX1.7B25.3851.8823.31
Xencor IncXNCR1.7B24.0126.8415.70
Dynavax Technologies CorporationDVAX1.7B12.7614.9810.05
Kadmon Holdings IncKDMN1.7B9.509.503.46
Arcutis Biotherapeutics IncARQT1.7B14.1114.993.02
Constellation Pharmaceuticals IncCNST1.6B33.9937.0017.62
Eidos Therapeutics IncEIDX1.5B0.0066.5624.50
BioCryst Pharmaceuticals IncBCRX1.5B7.398.694.13
Akcea Therapeutics IncAKCA1.5B0.0025.668.00
Zogenix IncZGNX1.5B26.6826.6811.25
Viridian Therapeutics IncVRDN1.5B18.7325.7111.60
Kiniksa Pharmaceuticals LtdKNSA1.5B20.4927.5916.88
Immunocore Holdings LtdIMCR1.4B28.4275.3628.26
Nurix Therapeutics IncNRIX1.4B20.0428.147.77
Arcus Biosciences IncRCUS1.4B15.4620.1813.69
Portola Pharmaceuticals IncPTLA1.4B0.0031.735.31
Novavax IncNVAX1.4B8.6820.973.76
Maravai Lifesciences Holdings IncMRVI1.4B5.4311.344.42
Praxis Precision Medicines IncPRAX1.4B72.8484.8320.90
Sierra Oncology IncSRRA1.3B54.9954.9915.51
Ocular Therapeutix IncOCUL1.3B8.4511.473.85
Aurinia Pharmaceuticals IncAUPH1.3B9.0410.444.81
Intellia Therapeutics IncNTLA1.2B12.0832.8012.02
Arvinas IncARVN1.2B17.8352.3117.83
Rocket Pharmaceuticals IncRCKT1.2B11.3531.9411.35
CTi Biopharma CorpCTIC1.2B9.099.104.08
Mesoblast LtdMESO1.1B16.7616.761.72
Innoviva IncINVA1.1B17.9320.3214.40
Ardelyx IncARDX1.1B4.699.744.50
Syndax Pharmaceuticals IncSNDX1.1B12.8524.8112.85
Aimmune Therapeutics IncAIMT1.1B0.0037.0010.09
Bicycle Therapeutics LtdBCYC1B15.0027.5113.81
Pharvaris BVPHVS1B19.0132.0715.67
Vir Biotechnology IncVIR1B7.3712.666.74
Forma Therapeutics Holdings IncFMTX1B20.0120.315.10
Gracell Biotechnologies Inc.GRCL1B10.2510.351.45
Zymeworks Inc. Common StockZYME0.9B13.5817.408.11
Replimune Group IncREPL0.9B12.0114.935.01
Poseida Therapeutics IncPSTX0.9B9.419.512.00
Albireo Pharma IncALBO0.9B44.1544.9516.32
Nuvation Bio IncNUVB0.9B2.693.971.46
Liquidia Technologies IncLQDA896.3M10.5916.738.90
Adaptive Biotechnologies CorpADPT885.5M6.006.782.34
Cogent Biosciences IncCOGT861.6M7.8012.304.38
Prothena Corporation plcPRTA861.5M16.0140.6611.95
Immatics NVIMTX836.3M6.8813.496.73
89bio IncETNB826.6M7.0313.777.03
Pliant Therapeutics IncPLRX809.4M13.3019.5910.52
Abcellera Biologics IncABCL800.4M2.715.972.39
Intercept Pharmaceuticals IncICPT792.7M19.0021.719.17
Avid Bioservices IncCDMO784.7M12.3312.455.86
Zealand Pharma A/S ADRZEAL778.8M17.5932.9410.05
Uniqure NVQURE754.1M15.4717.403.78
Tyra Biosciences IncTYRA733.7M14.5028.6111.61
Anavex Life Sciences CorpAVXL718.2M8.479.913.39
Relay Therapeutics IncRLAY713.1M4.2612.074.16
Kura Oncology IncKURA697.5M8.9723.538.97
Immunome IncIMNM691.6M11.0827.349.33
Keros Therapeutics IncKROS685.4M16.9270.4816.92
CureVac NVCVAC670.8M2.994.992.31
Travere Therapeutics IncRTRX665.9M0.0021.918.98
Stemline Therapeutics IncSTML638.5M0.0017.663.43
Mereo BioPharma Group PLC ADRMREO630.8M3.294.872.30
Exscientia Ltd ADREXAI613.6M4.847.513.99
Arbutus Biopharma CorpABUS608.3M3.214.562.26
Stoke Therapeutics IncSTOK598.5M11.3017.524.12
Autolus Therapeutics LtdAUTL596.1M2.247.292.24
Omeros CorporationOMER593.4M10.2412.152.88
Capricor Therapeutics IncCAPR586.6M12.9021.993.56
Altimmune IncALT581.8M8.1813.815.50
BioDelivery Sciences International IncBDSI576M5.595.602.56
Sangamo Therapeutics IncSGMO563.2M2.312.870.32
Annexon IncANNX556.4M5.227.814.03
Savara IncSVRA554.3M3.235.592.94
Oric Pharmaceuticals IncORIC542.7M7.6916.036.63
CorMedix IncCRMD538.2M8.8713.592.94
Phathom Pharmaceuticals IncPHAT534.7M7.8219.506.21
Astria Therapeutics IncATXS533.3M9.4516.696.99
Urovant Sciences LtdUROV531.4M0.0016.247.39
AVEO Pharmaceuticals IncAVEO521.4M15.0015.003.15
Terns Pharmaceuticals IncTERN513.9M6.0511.234.54
Prevail Therapeutics IncPRVL508.6M0.0019.257.41
Xeris Pharmaceuticals IncXERS508.4M3.413.731.70
PureTech Health PLCPRTC504.7M21.0832.9819.29
Opthea LtdOPT504.2M3.235.131.86
SIGA Technologies IncSIGA504.1M6.0311.974.20
Ginkgo Bioworks HoldingsDNA502.4M8.7471.605.36
Harpoon Therapeutics IncHARP492.3M23.0123.013.29
Eyepoint Pharmaceuticals IncEYPT485.9M7.1229.717.10
Akouos IncAKUS485.8M13.2913.512.46
Theravance Biopharma IncTBPH478.5M9.7311.597.66
Sinovac Biotech Ltd.SVA460.2M0.006.476.47
Kodiak Sciences IncKOD456.8M8.6810.152.20
AnaptysBio IncANAB456.4M15.0040.3314.55
MeiraGTx Holdings PLCMGTX456.4M5.847.333.88
UroGen Pharma LtdURGN452M10.7119.3310.64
Esperion Therapeutics IncESPR428.6M2.183.831.61
Olema Pharmaceuticals IncOLMA427.3M5.7916.625.79
BioSpecifics Technologies CorpBSTC420.4M0.0065.8742.00
IGM Biosciences IncIGMS419.2M7.0517.836.28
Codexis IncCDXS416.7M5.125.812.59
Chromadex CorpCDXC413.2M5.417.721.36
Arcturus Therapeutics Holdings IncARCT402M14.8444.3914.82
Concert Pharmaceuticals IncCNCE401.9M8.378.402.73
Monte Rosa Therapeutics IncGLUE400M6.5110.363.38
Kalvista Pharmaceuticals IncKALV399.8M8.0916.048.09
Akebia TherAKBA390.5M1.792.240.86
Allogene Therapeutics IncALLO385.8M1.845.631.84
Y mAbs TherapeuticsYMAB383.8M8.5718.696.57
Taysha Gene Therapies IncTSHA379.1M1.854.171.27
Orchard Therapeutics PLCORTX379M16.7016.704.58
G1 Therapeutics IncGTHX377.2M7.157.151.12
Trevi Therapeutics IncTRVI370.9M4.154.501.30
PDL BioPharma IncPDLI370M0.003.862.06
Regenxbio IncRGNX367.1M7.4124.617.41
Sana Biotechnology IncSANA357.2M1.6011.271.60
Valneva SE ADRVALN353.2M4.3510.763.69
Aquestive Therapeutics IncAQST331.9M3.646.092.00
Corvus Pharmaceuticals IncCRVS327.1M5.099.561.36
Immutep Ltd ADRIMMP326.5M2.123.231.77
Progenics Pharmaceuticals IncPGNX321.3M0.006.311.89
Revance TheRVNC320.5M3.079.312.34
Vanda Pharmaceuticals IncVNDA314.9M4.636.503.47
Voyager Therapeutics IncVYGR310.8M5.6910.845.27
Sage TherapeuticSAGE305.9M5.0026.954.78
Rigel Pharmaceuticals IncRIGL303.2M17.2127.887.73
Oyster Point Pharma IncOYST299.9M11.1716.603.60
Silence Therapeutics PLCSLN299.3M6.3426.256.33
Cardiff Oncology IncCRDF298.7M4.495.911.45
XOMA CorpXOMA295.9M25.1133.8818.50
Cerus CorporationCERS293.4M1.582.421.52
Cerecor IncCERC289.9M2.934.342.02
Aldeyra TheALDX289.4M4.866.322.77
Cellular Biomedicine Group IncCBMG279.6M0.0018.9910.98
Foghorn Therapeutics IncFHTX276.9M4.989.992.82
ProQR Therapeutics BVPRQR274.3M2.594.491.64
Amylyx Pharmaceuticals IncAMLX271.4M3.9619.571.62
4D Molecular Therapeutics IncFDMT267.2M5.7835.875.78
AC Immune LtdACIU267.1M2.705.002.29
Atea Pharmaceuticals IncAVIR264.4M3.134.562.93
Iteos Therapeutics IncITOS263.8M7.2218.097.22
Bright Minds Biosciences IncDRUG262.3M39.1155.770.96
Lexicon Pharmaceuticals IncLXRX261.6M0.723.580.65
Chimerix IncCMRX256.3M2.852.990.77
Larimar Therapeutics IncLRMR254M3.9813.283.98
Chiasma IncCHMA253M3.765.502.82
Eledon Pharmaceuticals IncELDN252.1M4.225.301.54
Epizyme IncEPZM250.8M1.475.730.42
Cidara Therapeutics IncCDTX246.2M22.5123.7310.17
Rezolute IncRZLT245.1M4.235.960.90
Abeona Therapeutics IncABEO244.7M5.638.683.17
Anika Therapeutics IncANIK239.2M16.3328.7516.04
Aduro Biotech IncADRO238.2M0.004.040.90
Eton Pharmaceuticals IncETON236.9M12.2813.533.06
AMAG Pharmaceuticals IncAMAG235.1M0.0013.534.41
Heron TherapeutiHRTX232.7M1.533.861.06
Checkmate Pharmaceuticals IncCMPI231.2M10.5010.502.02
Menlo Therapeutics IncMNLO230.3M0.007.481.00
Inventiva SaIVA229.8M2.374.701.65
Pfenex IncPFNX224.6M0.0013.955.26
Merrimack Pharmaceuticals IncMACK223.7M15.1315.1311.60
Ocugen IncOCGN223.7M0.771.980.50
Fulcrum Therapeutics IncFULC217.4M4.0312.002.97
Benitec Biopharma Ltd ADRBNTC215.4M12.1713.082.80
Mersana Therapeutics IncMRSN214.9M1.745.941.23
Precigen IncPGEN212.6M0.731.880.67
Inhibikase Therapeutics IncIKT212.3M3.163.971.13
Spectrum Pharmaceuticals IncSPPI211.4M1.031.560.32
Silverback Therapeutics IncSBTX209.5M5.878.692.90
Zentalis Pharmaceuticals LlcZNTL208.8M2.9316.492.70
DiaMedica Therapeutics IncDMAC208.2M4.876.412.16
Avid Bioservices IncCDMOP205M0.0030.5619.82
ADC Therapeutics SAADCT205M2.125.291.59
Inhibrx IncINBX200.9M13.8839.5611.04
KemPharm IncKMPH200.5M5.406.854.02
MacroGenics IncMGNX199.6M3.1821.473.00
Aclaris Therapeutics IncACRS197.9M2.774.590.92
Verastem IncVSTM197.6M4.4414.072.20
XBiotech IncXBIT193.3M6.349.893.93
Vaccitech PLC ADRVACC192.7M3.525.001.68
Molecular Partners AG ADRMOLN192.4M5.2211.013.32
Amarin Corporation PLCAMRN191.5M0.471.350.45
Gossamer Bio IncGOSS190.6M0.841.510.51
Fate Therapeutics IncFATE189.1M1.668.351.66
ZIOPHARM Oncology IncZIOP188.8M0.875.600.82
Compass Therapeutics Inc.CMPX188.5M1.372.290.80
Lyell Immunopharma IncLYEL187.3M0.643.070.60
GenfitGNFT185.7M3.726.333.34
Mediwound LtdMDWD185.6M17.2021.1610.17
Inozyme Pharma IncINZY180.5M2.817.662.48
Innate PharmaIPHA178.8M2.163.021.44
Protara Therapeutics IncTARA177.8M5.186.671.62
Alector IncALEC174.3M1.788.081.78
Contextlogic IncLOGC174.3M6.638.074.12
Nektar TherapeuticsNKTR173.6M0.941.830.49
NanobiotixNBTX173.1M3.288.132.81
Coherus BioSciences IncCHRS170.5M1.483.330.67
Scpharmaceuticals IncSCPH165.6M3.316.403.14
Greenwich Lifesciences IncGLSI164.6M12.5220.328.31
Checkpoint Therapeutics IncCKPT164.6M3.374.391.39
Skye Bioscience, Inc. Common StockSKYE163.5M2.8618.002.25
Cellectis SACLLS163.5M1.593.491.59
Progenity IncPROG162.9M0.694.890.67
Corbus Pharmaceuticals HoldingCRBP162.4M13.3361.555.40
Fennec Pharmaceuticals IncFENC160.5M5.8411.613.99
Seres Therapeutics IncMCRB157.2M0.921.560.55
FStar Therapeutics IncFSTX156.5M7.127.122.18
Nkarta IncNKTX155.3M2.2015.712.17
La Jolla Pharmaceutical CoLJPC155.1M6.226.223.12
Adaptimmune Therapeutics PlcADAP153.5M0.601.750.58
Sutro BiopharmaSTRO150.1M1.825.651.82
Imara IncIMRA149.8M6.326.320.99
Aligos Therapeutics IncALGS137.6M38.3539.846.89
Vaxart IncVXRT137.2M0.601.410.53
Seer IncSEER136.8M2.322.551.54
Puma Biotechnology IncPBYI136.5M2.787.402.25
CompugenCGEN136.1M1.522.951.41
Selecta Biosciences, Inc.SELB135.2M0.751.890.67
Strongbridge Biopharma plcSBBP133.6M2.003.961.89
Achieve Life Sciences IncACHV131.4M3.825.503.69
aTyr Pharma IncLIFE131.1M1.982.451.11
NGM Biopharmaceuticals IncNGM130.2M1.544.530.60
Protalix Biotherapeutics IncPLX128.1M1.741.840.90
Decibel Therapeutics IncDBTX127.1M4.915.231.86
Monopar Therapeutics IncMNPR125.6M23.7932.661.55
Paratek Pharmaceuticals IncPRTK125.5M2.233.561.37
Galectin Therapeutics IncGALT125.5M2.004.201.04
InflaRx N.V.IFRX125.4M2.132.621.18
Sio Gene Therapies IncAXGT125.3M0.008.081.41
Kinnate Biopharma IncKNTE125M2.656.691.07
Enanta Pharmaceuticals IncENTA124.2M5.8617.465.85
Black Diamond Therapeutics IncBDTX123.9M2.197.392.19
Atossa Genetics IncATOS123.3M0.982.100.80
Graybug Vision IncGRAY121M2.9510.500.47
Forte Biosciences IncFBRX119.3M18.6628.004.18
Sesen Bio IncSESN119.3M0.630.930.24
Applied Therapeutics IncAPLT118.7M1.0210.240.88
Allakos IncALLK115.3M1.293.230.54
Catabasis Pharmaceuticals IncCATB114.3M8.5442.007.32
Cabaletta Bio IncCABA112.9M2.3125.381.87
Lineage Cell Therapeutics IncLCTX110.6M0.501.480.50
Editas Medicine IncEDIT110.6M1.3411.071.31
Cassava Sciences IncSAVA110.2M2.2935.082.29
Opiant Pharmaceuticals IncOPNT109.4M20.6526.989.38
Adagene IncADAG108.5M2.014.151.66
Acumen Pharmaceuticals IncABOS108.1M1.804.641.79
Cleveland BioLabs IncCBLI107.7M3.129.551.84
Aerpio Pharmaceuticals IncARPO107M2.202.790.96
Tonix Pharmaceuticals Holding CorpTNXP106.5M0.5713.370.13
Leap Therapeutics IncLPTX106.5M2.784.781.69
MediciNova IncMNOV105.9M2.162.381.13
Entasis Therapeutics Holdings IncETTX105.3M2.193.771.45
X4 Pharmaceuticals IncXFOR103.6M0.611.470.28
Champions Oncology IncCSBR103.4M7.557.553.79
Regulus Therapeutics IncRGLS101.5M1.552.881.13
Jounce Therapeutics IncJNCE100.5M1.885.490.64
Assembly Biosciences IncASMB100.5M15.8119.439.57
INmune Bio IncINMB98M4.4214.014.40
Adverum Biotechnologies IncADVM97.8M4.7028.104.70
Oramed Pharmaceuticals IncORMP94.6M2.493.582.07
Immunic IncIMUX93.7M1.041.950.98
Osmotica Pharmaceuticals plcOSMT92.5M1.084.710.98
Miromatrix Medical IncMIRO92.4M3.394.100.92
Milestone Pharmaceuticals IncMIST91.5M1.722.201.29
Proteostasis Therapeutics IncPTI91.3M0.004.720.61
Viridian Therapeutics IncMGEN89.9M0.0024.935.88
Bluebird bio IncBLUE89.7M9.2335.005.96
BioNTech US IncNTGN88.9M0.005.650.88
Citius Pharmaceuticals IncCTXR87.1M2.5725.752.57
Berkeley Lights IncBLI86.6M0.875.840.79
CASI Pharmaceuticals IncCASI86.6M2.697.852.24
Tiziana Life Sciences LtdTLSA86.4M0.831.450.42
CytomX Therapeutics IncCTMX86.1M1.105.130.86
I-MabIMAB85.7M0.952.370.92
Allovir IncALVR85.3M0.451.010.40
Karyopharm Therapeutics IncKPTI82M0.651.660.64
Entera Bio LtdENTX79.6M2.162.980.55
Alx Oncology Holdings ALXO78.1M1.4817.561.21
Pmv Pharmaceuticals IncPMVP77.6M1.503.261.44
Biofrontera AGBFRA75.7M2.677.252.50
Aerovate Therapeutics IncAVTE73.1M2.5330.751.41
Ovid Therapeutics IncOVID72.4M1.024.040.70
Generation Bio CoGBIO72.1M1.084.351.02
Landos Biopharma IncLABP71.7M22.9322.932.75
Armata Pharmaceuticals IncARMP71.6M1.984.181.95
ESSA Pharma IncEPIX71M1.6010.651.40
Oncolytics Biotech IncONCY70.7M0.891.400.74
resTORbio IncTORC70.7M0.0011.960.87
Clearside Biomedical IncCLSD70.5M0.932.020.87
BeyondSpring IncBYSI68.9M1.553.630.85
Cortexyme IncCRTX68.7M1.95120.211.84
Reviva Pharmaceuticals Holdings Inc.RVPH68.2M1.505.520.64
Vigil Neuroscience IncVIGL67.9M1.664.661.65
Zivo Bioscience IncZIVO66.8M17.600.000.00
Inovio Pharmaceuticals IncINO66.6M1.8513.881.78
Surface Oncology IncSURF65.7M1.071.400.57
PDS Biotechnology CorpPDSB65.5M1.756.591.65
Agenus IncAGEN65.2M2.7618.562.57
DBV TechnologiesDBVT65.1M3.0510.402.35
Cue BiopharmaCUE64.6M1.023.100.45
AVROBIO IncAVRO63.7M1.401.620.89
Sellas Life Sciences Group IncSLS63.2M0.901.630.51
VistaGen Therapeutics IncVTGN62.6M2.255.772.25
Tcr2 Therapeutics IncTCRR62M1.483.750.83
Verrica Pharmaceuticals IncVRCA61.2M0.689.560.64
Heat Biologics Inc.HTBX61M2.419.602.10
Vor Biopharma IncVOR60.9M0.892.850.64
Annovis Bio IncANVS60.7M4.4019.624.37
Gemini Therapeutics IncGMTX58.5M21.2221.220.00
Bioatla IncBCAB57.5M1.193.920.69
Atara Biotherapeutics IncATRA57.2M9.9330.506.81
Sigilon Therapeutics IncSGTX56.1M22.4723.063.80
Repare Therapeutics IncRPTX56.1M1.328.411.26
Connect Biopharma Holdings LtdCNTB54.8M0.992.200.94
Spero Therapeutics IncSPRO54.4M1.001.800.96
Homology Medicines IncFIXX53.9M0.931.430.53
Rafael Holdings Inc Class BRFL53.5M1.802.371.36
Renovacor IncRCOR52.7M3.209.391.56
Tyme Technologies IncTYME49.5M0.311.140.23
Cancer Genetics IncCGIX49.2M0.008.602.20
Prelude Therapeutics IncPRLD48.9M0.896.370.80
Aeglea Bio Therapeutics IncAGLE48.6M27.6027.662.66
Iterum Therapeutics PLCITRM48.2M1.752.910.91
Kezar Life Sciences IncKZR47.6M6.5210.505.29
Nutriband IncNTRB47.4M4.279.252.30
Erytech Pharma S.A. ADRERYP47.4M0.701.380.33
Fortress Biotech IncFBIO46.9M1.743.891.39
vTv Therapeutics IncVTVT45.9M14.5229.017.89
Magenta Therapeutics IncMGTA45.1M13.2213.220.36
CEL-SCI CorpCVM44.7M0.773.080.50
Enochian Biosciences IncENOB44.6M1.562.600.40
Purple Biotech LtdKTOV44.5M0.001.080.22
Vyne Therapeutics IncVYNE44.3M2.393.281.60
Sunesis Pharmaceuticals IncSNSS43.9M0.001.190.20
Odonate Therapeutics IncODT43.1M1.4026.211.02
Collplant Biotechnologies LtdCLGN42.1M3.686.753.41
Achilles Therapeutics PLC ADRACHL41.9M0.981.570.70
Gain Therapeutics IncGANX41.6M1.575.040.94
Exicure IncXCUR41M15.7431.991.50
Passage Bio IncPASG40.4M0.651.730.47
Auris Medical Holding LtdEARS39.2M3.055.230.76
Aileron Therapeutics IncALRN38.1M1.766.931.65
LianBio ADRLIAN37.6M0.324.990.32
Lumos Pharma IncLUMO37.5M4.344.451.45
OncoCyte CorpOCX37.2M2.213.602.19
Biovie IncBIVI37M2.0818.901.10
Acasti Pharma IncACST36.5M3.373.602.05
4D Pharma PLC ADRLBPS36.3M1.6511.001.56
Fortress Biotech Inc Pref Series AFBIOP36.2M6.7517.095.00
FibroGen IncFGEN35.6M0.352.730.30
Satsuma Pharmaceuticals IncSTSA35.6M1.107.950.61
Precision BioSciences IncDTIL35.3M4.6018.564.13
Sio Gene Therapies IncSIOX35.1M0.480.480.36
Anchiano Therapeutics LtdANCN34.9M0.00127.3610.42
Actinium Pharmaceuticals IncATNM34.9M1.129.891.12
Ocuphire Pharma IncOCUP34.8M1.173.271.17
ARCA Biopharma IncABIO34.8M2.403.880.98
Lantern Pharma IncLTRN34.6M3.2110.652.94
Dyadic International IncDYAI33.6M1.912.270.99
PluristemPSTI33.3M1.003.411.00
Marker Therapeutics IncMRKR33.3M3.735.962.49
AzurRx BioPharma IncAZRX33.1M3.4521.703.38
OUTLOOK THERAPEUTICS INCOTLK32.9M1.3911.941.39
ImmuCell CorporationICCC32.1M4.585.483.53
AgeX Therapeutics IncAGE31.5M11.1031.4411.10
Tempest Therapeutics IncTPST31.4M0.725.440.70
Caladrius Biosciences IncCLBS30.9M0.431.220.41
Chemomab Therapeutics Ltd DRCCMMB30.5M1.622.460.50
Akari Therapeutics PLCAKTX30.3M1.004.300.95
Zafgen IncZFGN30.3M0.002.830.62
Angion Biomedica CorpANGN29.5M1.002.020.48
Ritter Pharmaceuticals IncRTTR29.1M0.001.230.15
Seneca Biopharma IncSNCA28.5M0.002.060.53
Freeline Therapeutics Holdings PlcFRLN28.2M6.488.272.22
RAPT Therapeutics IncRAPT28.2M0.8126.450.81
Tocagen IncTOCA28.2M0.009.180.42
Kala Pharmaceuticals IncKALA27.7M6.009.004.60
Liminal BioSciences IncLMNL27.4M8.508.503.25
Anpac Bio Medical Science Co LtdANPC27M3.8010.322.80
NextCure  IncNXTC26.6M0.952.490.89
Idera Pharmaceuticals IncIDRA26.5M5.219.210.23
Cognition Therapeutics IncCGTX26.3M0.632.620.38
Applied GeneticAGTC26.3M0.392.710.23
Curis IncCRIS26M3.0716.803.07
Briacell Therapeutics CorpBCTX26M0.595.850.47
AEON Biopharma, Inc.AEON26M0.6516.290.53
Enlivex Therapeutics LtdENLV25.9M1.184.310.84
Dare Bioscience IncDARE25.9M2.987.322.71
Metacrine IncMTCR25.8M0.580.590.35
Hookipa Pharma IncHOOK25.8M2.1410.402.00
Lipocine IncLPCN25M4.6810.692.79
AB Corporate Bond ETFEYEG24.7M35.370.000.00
Spring Bank Pharmaceuticals IncSBPH23.9M0.007.250.80
Stealth BioTherapeutics CorpMITO23.9M0.320.980.18
PolyPidPYPD23.8M3.507.742.43
Ibio IncIBIO23.3M2.424.061.05
9 Meters Biopharma IncINNT23.1M0.001.600.37
Alterity Therapeutics LtdATHE22.6M2.102.941.05
Cara TherapeuticCARA22.4M0.411.050.24
GeoVax Labs IncGOVX21.9M2.328.351.11
Pulmatrix IncPULM21.6M5.917.341.62
Cocrystal Pharma IncCOCP21.4M2.102.801.40
Equillium IncEQ21.3M0.603.000.60
Athira Pharma IncATHA21.2M0.554.150.42
Pieris Pharmaceuticals IncPIRS21.1M13.6018.476.53
Onconova Therapeutics IncONTX21M1.001.420.62
Eledon Pharmaceuticals IncNVUS21M0.0026.184.68
Yumanity Therapeutics IncYMTX20.5M1.893.530.97
BioLineRx LtdBLRX20.4M0.201.610.20
Neurobo Pharmaceuticals IncNRBO20.3M2.256.522.19
Millendo Therapeutics IncMLND20.2M1.062.730.93
Palatin Technologies IncPTN20.2M0.865.460.75
Conatus Pharmaceuticals IncCNAT19.9M0.001.070.23
Mink Therapeutics IncINKT19.8M0.501.560.46
Acer Therapeutics IncACER19.7M0.660.000.00
VIVUS IncVVUS19.7M0.004.750.80
Aikido Pharma IncAIKI19.5M3.907.970.00
Catalyst Biosciences IncCBIO19.4M23.3126.302.83
Affimed NVAFMD19.3M1.187.331.18
Bolt BiotherapeuticsBOLT19.3M0.501.500.50
Finch Therapeutics Group IncFNCH19.3M12.0013.690.88
ImmunoCellular Therapeutics LtdIMUC19.1M0.170.400.08
Tenax Therapeutics IncTENX19M5.5626.402.77
Mawson Infrastructure Group IncMIGI18.9M1.014.310.68
NanoViricides IncNNVC18.8M1.453.311.02
Nymox Pharmaceutical CorpNYMX18.3M0.631.030.19
Cyclo Therapeutics IncCYTH17.8M0.621.900.58
Intec Pharma LtdNTEC17.7M8.8733.588.87
Aprea Therapeutics IncAPRE17.6M3.238.462.54
Aeterna Zentaris IncAEZS17.5M6.1411.924.41
In8bio IncINAB17.4M0.241.690.23
Cogent Biosciences IncUMRX16.8M0.003.650.30
Neuraxis, Inc.NRXS16.8M2.403.802.10
Unity Biotechnology IncUBX16.3M0.971.990.96
MEI Pharma IncMEIP16.3M2.456.152.45
Synthetic Biologics IncSYN16.2M0.724.300.61
Synlogic IncSYBX16M1.374.781.36
Tetraphase Pharmaceuticals IncTTPH15.9M0.006.170.23
Spruce Biosciences IncSPRB15.8M0.385.490.38
BioXcel Therapeutics IncBTAI15.2M0.324.040.32
Minerva Neurosciences IncNERV15M2.1412.472.10
Cardiff Oncology IncTROV14.6M0.003.460.70
Celyad SACYAD14.2M0.512.450.15
Celsion CorpCLSN13.9M1.9615.751.81
Forward Pharma A SFWP13.8M2.566.030.00
Evaxion Biotech ASEVAX13.3M0.8910.650.88
GlycoMimetics IncGLYC13.3M0.213.490.14
Kazia Therapeutics Ltd ADRKZIA13.2M3.0312.401.92
Marinus Pharmaceuticals IncMRNS13.2M0.2411.210.23
Immunoprecise Antibodies LtdIPA13M0.422.410.35
Cellect Biotechnology LtdAPOP12.9M13.1726.806.84
Sqz Biotechnologies CoSQZ12.8M0.053.350.05
Sol Gel Technologies LtdSLGL12.3M0.441.500.37
Applied Molecular Transport IncAMTI12.2M0.260.680.14
AIM ImmunoTech IncAIM12.2M0.190.610.18
Vascular Biogenics LtdVBLT12.1M2.766.740.11
Kintara Therapeutics IncKTRA12M6.30151.552.93
Brainstorm Cell Therapeutics IncBCLI11.9M2.0811.101.13
Clovis Oncology IncCLVS11.8M0.082.960.00
Cyclacel Pharmaceuticals IncCYCCP11.5M6.0522.005.58
PharmaCyte Biotech IncPMCB11.4M1.642.521.47
Immuron Ltd ADRIMRN11.4M2.004.551.65
Medicenna Therapeutics CorpMDNA11.2M0.300.820.16
Lyra Therapeutics IncLYRA11.1M0.176.530.17
ObsEva SAOBSV11M0.082.080.08
Frequency Therapeutics IncFREQ10.9M0.305.480.22
Curative Biotechnology IncCUBT10.8M0.010.040.00
Sensei Biotherapeutics IncSNSE10.8M0.431.840.41
Vincerx Pharma IncVINC10.5M0.218.060.19
Biomx IncPHGE10.3M0.576.880.49
Jaguar Animal Health IncJAGX10.3M0.8719.080.86
BioPharmX CorporationBPMX10.3M0.001.180.25
Aptose Biosciences IncAPTO10.1M0.172.560.17
BioRestorative Therapies IncBRTX10M1.453.451.15
Eyenovia IncEYEN10M0.092.370.08
Cellectar Biosciences IncCLRB9.8M0.244.240.24
IMV Inc.IMV9.8M0.107.570.05
Can Fite Biopharma Ltd ADRCANF9.4M1.444.501.33
Rexahn Pharmaceuticals IncREXN9.4M0.005.771.26
Allena Pharmaceuticals IncALNA9.2M0.061.000.02
Purple BiotechPPBT9.1M3.4518.362.19
Diffusion Pharmaceuticals IncDFFN9M8.679.904.20
EvogeneEVGN8.9M1.299.801.24
Viracta Therapeutics IncVIRX8.5M0.211.170.14
Aytu BioScience IncAYTU8.5M1.383.361.34
Biocardia IncBCDA8.4M1.8410.201.84
Mustang Bio IncMBIO8.2M0.171.460.13
Kintara Therapeutics IncDMPI8.1M0.002.990.38
Coeptis Therapeutics IncCOEP8.1M0.140.820.14
Cyclerion Therapeutics IncCYCN8M2.956.351.36
XTL Biopharmaceuticals Ltd ADRXTLB7.9M1.463.330.80
Soligenix IncSNGX7.7M3.0815.032.00
Genprex IncGNPX7.7M0.9011.210.33
Ayala Pharmaceuticals IncAYLA6.9M0.506.750.38
Alzamend Neuro IncALZN6.8M1.2512.001.11
Orgenesis IncORGS6.8M1.409.990.89
Brickell Biotech IncBBI6.8M0.901.030.49
Adial Pharmaceuticals IncADIL6.7M1.053.260.82
Xenetic Biosciences IncXBIO6.6M4.284.723.15
Portage Biotech IncPRTG6.6M5.8537.802.16
Aptinyx IncAPTX6.5M0.100.690.05
Bio Path Holdings IncBPTH6.4M1.4911.200.61
ABVC Biopharma IncABVC6.3M0.521.930.47
GT Biopharma IncGTBP6.2M1.927.801.75
Galecto IncGLTO6.1M4.6622.284.66
Reneo Pharmaceuticals IncRPHM6.1M1.828.431.31
Edesa Biotech IncEDSA6.1M1.755.671.73
First Wave BioPharma IncFWBI6M2.9847.602.60
Ainos IncAIMD6M0.442.880.43
Plus Therapeutics IncPSTV5.8M0.992.600.99
Moleculin Biotech IncMBRX5.8M1.8114.251.67
NLS Pharmaceutics AGNLSP5.6M2.3823.601.85
Gritstone Oncology IncGRTS5.6M0.032.900.03
Syros Pharmaceuticals IncSYRS5.4M0.207.840.20
Vallon Pharmaceuticals IncVLON5.4M0.401.940.22
Hoth Therapeutics IncHOTH5.3M0.771.650.59
Cns Pharmaceuticals IncCNSP5.3M0.1164.000.10
Rubius Therapeutics IncRUBY5.2M0.060.340.02
Galmed Pharmaceuticals LtdGLMD5.1M3.0715.102.56
NanoString Technologies IncNSTG5.1M0.1710.400.04
BiondVax Pharmaceuticals Ltd ADRBVXV5M0.6710.960.62
Intellipharmaceutics International IncIPCIF5M0.150.150.02
Windtree Therapeutics IncWINT4.9M0.3313.140.32
Sonnet Biotherapeutics Holdings IncSONN4.8M1.5918.081.56
NuCana PLCNCNA4.7M1.2110.501.21
Oragenics IncOGEN4.6M0.386.840.27
Nabriva Therapeutics AGNBRV4.5M0.452.720.41
Gamida Cell LtdGMDA4.3M0.022.370.01
Lixte Biotechnology Holdings IncLIXT4.3M1.913.701.31
Aptorum Group Ltd Class AAPM4.1M0.7410.550.55
CytRx CorpCYTR4.1M0.180.670.08
Synaptogenix IncSNPX4.1M2.577.382.40
Protagenic TherapeuticsPTIX4M0.661.820.47
180 Life Sciences CorpATNF3.8M1.946.471.18
NextTrip IncNTRP3.8M4.185.311.50
Vaccinex IncVCNX3.8M0.850.000.00
Silo Pharma IncSILO3.7M0.843.470.84
Avenue Therapeutics IncATXI3.7M1.8025.671.66
Hepion Pharmaceuticals IncHEPA3.7M0.533.590.49
Atreca IncBCEL3.6M0.091.130.06
Creative Medical Technology Holdings IncCELZ3.5M2.006.452.00
PhaseBio Pharmaceuticals IncPHAS3.5M0.032.560.02
Titan Pharmaceuticals IncTTNP3.3M3.2310.003.23
Oncorus IncONCR3.3M0.130.450.01
Enveric Biosciences IncENVB3.3M0.331.660.32
Aditxt Inc. ADTX3.2M0.23265.200.19
Petros Pharmaceuticals IncPTPI3.1M0.311.720.25
Processa Pharmaceuticals IncPCSA3.1M0.948.690.85
Artelo Biosciences IncARTL3.1M0.951.730.95
Virpax Pharmaceuticals IncVRPX3M0.324.950.30
Qualigen Therapeutics IncQLGN3M4.0429.003.60
InMed Pharmaceuticals IncINM3M4.148.802.46
Aravive IncARAV2.9M0.042.460.04
Matinas BioPharma Holdings IncMTNB2.9M0.5718.490.53
Codiak BioSciences IncCDAK2.8M0.014.140.01
Novan IncNOVN2.6M0.032.240.02
BiophytisBPTS2.6M7.03124.405.92
Eiger Biopharmaceuticals IncEIGR2.6M2.0537.801.30
Zosano Pharma CorpZSAN2.5M0.5635.350.52
NovaBay Pharmaceuticals IncNBY2.5M0.507.520.38
Molecular Templates IncMTEM2.3M0.354.080.16
Aptevo Therapeutics IncAPVO2.3M4.53309.163.88
Oncternal Therapeutics IncONCT2.2M0.5312.800.53
Therapix Biosciences LtdTRPX2.2M0.003.400.25
Cyclacel Pharmaceuticals IncCYCC2.1M0.333.330.32
Salarius Pharmaceuticals IncSLRX2M1.415.441.22
Phio Pharmaceuticals CorpPHIO2M1.749.721.74
GlobeImmune IncGBIM2M0.000.000.00
Aslan Pharmaceuticals Ltd ADRASLN2M0.6021.880.60
Midatech Pharma PLC ADRMTP2M0.1316.200.13
VBI Vaccines IncVBIV1.9M0.031.350.03
Polarityte IncPTE1.8M0.071.420.06
Telesis Bio Inc.TBIO1.7M0.4014.040.37
Panbela Therapeutics IncPBLA1.7M0.310.000.00
OncoSec Medical IncONCS1.7M0.0015.240.00
Galera Therapeutics IncGRTX1.6M0.030.270.03
CohBar IncCWBR1.6M0.561.010.20
Trevena IncTRVN1.5M1.660.000.00
Kiromic Biopharma IncKRBP1.4M0.923.460.52
NeuBase Therapeutics IncNBSE1.4M0.384.120.38
InVivo Therapeutics Holdings CorpNVIV1.3M0.322.180.22
Vyant Bio IncVYNT1.2M0.191.210.14
Axcella Health IncAXLA1.2M0.4029.750.40
Timber Pharmaceuticals IncTMBR1.2M0.003.240.00
Ayala Pharmaceuticals Inc. ADXS1.2M0.031.310.00
PaxMedica, Inc. Common StockPXMD1.1M0.070.880.06
Acorda Therapeutics IncACOR1.1M0.6617.600.66
9 Meters Biopharma IncNMTR1M0.011.510.01
Evofem Biosciences IncEVFM1M0.010.070.01
Baudax Bio IncBXRX1M0.011.170.01
Ember Therapeutics IncEMBT0.9M0.000.000.00
Athersys IncATHX833.2K0.011.490.01
Bellicum Pharmaceuticals IncBLCM778.3K0.080.960.07
Emmaus Life Sciences IncEMMA740.8K0.010.130.00
Infinity Pharmaceuticals IncINFI726.1K0.000.740.00
Tff Pharmaceuticals IncTFFP722.9K0.078.990.07
Sorrento TherapeSRNE661.5K0.000.160.00
ContraFect CorpCFRX535.2K0.035.350.03
Otonomy IncOTIC514K0.012.510.01
TetraLogic Pharmaceuticals CorpTLOG458.7K0.000.000.00
Neximmune IncNEXI320.8K0.2315.190.20
Seelos Therapeutics IncSEEL313.8K0.39652.420.39
Bellerophon Therapeutics IncBLPH232.4K0.020.080.01
Virios Therapeutics LlcVIRI206.5K2.7421.001.85
TRACON Pharmaceuticals IncTCON148.3K0.0412.620.02
Adynxx IncADYX87.1K0.000.000.00
Histogen IncHSTO85.4K0.030.500.02
Evelo Biosciences IncEVLO28.5K0.000.400.00
Humanigen IncHGEN23.8K0.000.200.00
Navidea Biopharmaceuticals IncNAVB10K0.000.060.00
Scopus Biopharma IncSCPS8.4K0.000.050.00
Statera Biopharma IncSTAB7.1K0.000.000.00
Genocea Biosciences IncGNCA5.9K0.001.380.00
Aridis Pharmaceuticals IncARDS4.5K0.000.090.00
Kaleido Biosciences IncKLDO4.3K0.000.070.00
Ampio PharmAMPE3K0.005.760.00
Calithera Biosciences IncCALA4870.000.000.00
Eloxx Pharmaceuticals IncELOX3140.000.000.00
Immunovant IncIMVTU00.0028.4310.25
Pandion Therapeutics IncPAND00.00